Iryna Brodyak

Position: Associate Professor, Biochemistry Department

Scientific degree: Candidate of Biological Sciences

Academic status: Associate Professor

Phone (office): (032) 239-47-88

Email: iryna.brodyak@lnu.edu.ua

Web page: bioweb.lnu.edu.ua

Google Scholar profile: scholar.google.com.ua

ORCID profile: orcid.org

Scopus profile: www2.scopus.com

Web of Science (Publons) profile: publons.com

LinkedIn profile: www.linkedin.com

Research interests

Scientific interests: biochemical and morphofunctional characteristics of blood cells in various pathological conditions and the possibility of their correction by plant drugs.

The total number of scientific papers143, including: monograph ‑ 1 (in Ukrainian), textbooks – 2, manuals ‑ 11, articles in journals included in international bases Web of Science, Scopus ‑ 18, articles in professional journals of Ukraine ‑ 24, articles in other journal ‑ 4, abstracts at scientific conferences ‑ 81.

Co-author of the monograph “Essentials of Glycobiology”, textbooks “Chemistry of Protein” and “Functional biochemistry”. 

Publications

Articles:

  • Seniv M.B., Dzydzan O.V., Brodyak I.V., Kucharska A.Z., Sybirna N.O. Antioxidant effect of extract of yellow fruits of cornelian cherry (Cornus mas L.) in rats’ leukocytes under streptozotocin-induced diabetes mellitus. <em>Studia Biologica</em>. 2021: 15(1); 15–26. (https://doi.org/10.30970/sbi.1501.645).
  • Dzydzan O., Brodyak I., Sokół-Łętowska A., Kucharska A. Z., Sybirna N. Loganic Acid, an Iridoid Glycoside Extracted from Cornus mas L. Fruits, Reduces of Carbonyl/Oxidative Stress Biomarkers in Plasma and Restores Antioxidant Balance in Leukocytes of Rats with Streptozotocin-Induced Diabetes Mellitus. <em>Life</em>. 2020. 10(12), 349. (IF: 2.991) (https://doi.org/10.3390/life10120349).
  • Dzydzan O., Bila I., Kucharska A.Z., Brodyak I., Sybirna N. Antidiabetic effects of extracts of red and yellow fruits of cornelian cherries (Cornus mas L.) on rats with streptozotocin-induced diabetes mellitus. Food & Function. 2019. 10: 6459–6472. (IF: 4.171) (http://dx.doi.org/10.1039/c9fo00515c).
  • Strugała P., Dzydzan O., Brodyak I., Kucharska A.Z., Kuropka P., Liuta M., Kaleta-Kuratewicz K., Przewodowska A., Michałowska D., Gabrielska J., Sybirna N. Antidiabetic and Antioxidative Potential of the Blue Congo Variety of Purple Potato Extract in Streptozotocin-Induced Diabetic Rats. Molecules. 2019. 24(17): 3126. (IF: 3.060) (http://dx.doi.org/10.3390/molecules24173126).
  • Bila I., Dzydzan O.,Brodyak I., Sybirna N. Agmatine prevents oxidative-nitrative stress in blood leukocytes under streptozotocin-induced diabetes mellitus. Open Life Sciences. 2019. 14: 299–310. (IF: 0.504) (http://dx.doi.org/10.1515/biol-2019-0033).
  • Brodyak I.V., Bila I.I., Sybirna N.O. Effect of Agmatine on Actin Polymerization Dynamics in WGA-Stimulated Leukocytes under Diabetes Mellitus in Rats. International Journal of Physiology and Pathophysiology. 2018. 9(2): 109–118.
  • Brodyak I.V., Bila I.I., Sybirna N.O. The dynamics of actin filament polymerization in activated leukocytes under experimental diabetes mellitus against the background of agmatine administration. Biopolymers and Cell. 2017. 33(6): 403–414. (http://dx.doi.org/10.7124/bc.000964).
  • Ferents I.V., Brodyak I.V., Lyuta M.Ya., Burda V.A., Sybirna N.O. Suppressive effect of agmatine on genetically programmed death of leukocytes in a diabetes model. Cytology and Genetics. 2016. 50(4): 241–250. (IF: 0.379)
  • Brodyak I.V., Bila I.I., Overchuk M., Sybirna N.O. Effect of agmatine on actin polymerization in leukocytes of streptozotocin-induced diabetic rats. Studia Biologica. 2014. 8(3–4): 17–30. (https://doi.org/10.30970/sbi.0803.377)
  • Ferents I., Brodyak І., Lyuta M., Sybirna N. Structural and quantitative changes of carbohydrate chain of erythrocyte membrane glycoproteins in experimental diabetes mellitus after treatment with agmatine. Cytology and Genetics. 2013. 47(4): 252–260. (IF: 0,294)
  • Sybirna N.O., Brodyak I.V., Barska M.L., Vovk O.I. Participation of Phosphatidylinositol-3′-kinase in Perception and Signal Transduction through Galactosyl-Containing Glycoprotein Receptors of Segmented Leukocytes under Type 1 Diabetes Mellitus. International Journal of Physiology and Pathophysiology. 2013. 4: 213–230.
  • Sybirna N., Brodyak I., Zdioruk M., Barska M. Sialic acid-containing glycoproteins are the marker molecules that determine the leukocyte functional state under diabetes mellitus. Sepsis. 2011. 4(1): 47–55.

Biography

EDUCATION:

2003 – 2006PhD student at the Department of Biochemistry, Ivan Franko National University of Lviv, Ukraine
2002 – 2003M.Sc. in Biochemistry, Ivan Franko National University of Lviv, Ukraine
1998 – 2002B.Sc. in Biology, Ivan Franko National University of Lviv, Ukraine
1996 – 1998Graduated from Volyn scientific boarding lyceum, Lutsk, Volyn region, Ukraine
1987 – 1996Oshchiv secondary school of I-II grades, Gorokhiv district, Volyn region, Ukraine

PROFESSIONAL EXPERIENCE:

2012Received the Academic status – Associate Professor of Biochemistry
since 2011Associate professor at the Department of Biochemistry, Ivan Franko National University of Lviv, Ukraine
2006 – 2010Assistant рrofessor at the Department of Biochemistry, Ivan Franko National University of Lviv, Ukraine

MEMBERSHIPS:

  • The Ukrainian Society for Cell Biology
  • The Ukrainian Biochemical Society

Projects

2017 – 2019researcher of the project Bh-47F “Biochemical mechanisms of development, diagnosis and correction of diabetes-induced oxidative-nitrative stress” (state registration number: 0117U001225)
2013 – 2015researcher of the project “Mechanisms of correction of metabolic disorders of blood system cells in conditions of type 1 diabetes mellitus” (state registration number: 0113U003046)
2010 – 2012researcher of the project Bh-46F “The effect of the L-arginine / NO system on genetically programmed death of blood cells under type 1 diabetes mellitus”
2008 – 2010responsible researcher of the project 4281 from the Ukrainian Science and Technology Center “Development of test system for the molecular mechanisms of leukocyte aggregation ability study under diabetes mellitus”, Ivan Franko National University of Lviv
2007 – 2009research assistant involved in the research project F25.5/040 from the State Fund for Fundamental Research: “Study of the effect of nitric oxide (NO) on the processes of apoptosis and autophagy of malignant tumor cells with a deficiency of the main substrate of NO synthases”, Ivan Franko National University of Lviv
2007 – 2009researcher of the project Bh-90F “Biochemical mechanisms of regulation of the functional state of immunocompetent blood cells under type 1 diabetes mellitus”
2011 –2012individual grant from West-Ukrainian BioMedical Research Center (WUBMRC) “Evaluation of the effect of arginine deprivation-based enzymotherapy on human leukemic cells” (performers ‑ Brodyak I., Chen O.)
2007 – 2008individual grant from West-Ukrainian BioMedical Research Center (WUBMRC) “Іtudy of carbohydrate determinants of leucocyte glycoprotein receptors in patients with type 1 diabetes mellitus” (performer ‑ Brodyak I.)
2010internship at Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (Wrocław, Poland) in the Department of Immunochemistry from February 21 to March 6, 2010
2007internship at Jagiellonian University (Krakow, Poland) in the Department of Medical Chemistry, Medical College from May 28 to June 5, 2007

Awards

Course “Improvement of teaching skills”

Teaching materials

Textbook

  • Functional biochemistry: textbook: [for students of Higher education institution] / [N.O. Sybirna, G.Ya. Hachkova, I.V. Brodyak, K.A. Sibirna, M.R. Khokhla, M.V. Sabadashka]; Ed. by prof. N.O. Sybirna. Lviv: Ivan Franko National University of Lviv, 2018. 644 p. (Series “Studia Biologica”). (in Ukrainian)
  • Protein chemistry: textbook: [for students of Higher education institution] / [N.O. Sybirna, М. V. Gonchar, І. V. Brodyak, О. G. Stasyk, М. L. Barska]; Ed. by prof. N.O. Sybirna. Lviv: Ivan Franko National University of Lviv, 2010. 393 p. (Series “Studia Biologica”). (in Ukrainian)

 

Monograph:

  • Essentials of Glycobiology: monograph [N.O. Sybirna, А.І. Shevtsova, H.О. Ushakova, І.V. Brodyak, І.Y. Pismenetska]; Ed. by prof. N.O. Sybirna. Lviv: Ivan Franko National University of Lviv, 2015. 492 p. (in Ukrainian)

Schedule

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